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Fuskantar COVID-19 da ke canzawa akai-akai, hanyoyin gargajiya na jurewa ba su da ɗan tasiri.
Farfesa Huang Bo da Qin Chuan tawagar CAMS (Kwamitin Kimiyyar Kiwon Lafiya ta kasar Sin) sun gano cewa macrophages na alveolar da aka yi niyya sune ingantattun dabaru don sarrafa kamuwa da cutar COVID-19 da wuri, kuma sun gano magunguna biyu da aka saba amfani da su a cikin samfurin linzamin kwamfuta na COVID-19. Ana buga sakamakon bincike masu dacewa akan layi a cikin mujallar ilimi ta duniya, watsa sigina da jiyya da aka yi niyya.
"Wannan binciken ba wai kawai yana ba da ingantaccen magani mai inganci ga COVID-19 ba, har ma da yunƙuri mai ƙarfi na 'amfani da tsoffin magunguna don sabon amfani', yana ba da sabuwar hanyar tunani don zaɓar magunguna don COVID-19." Huang Bo ya jaddada a wata hira da wakilin kimiyya da fasaha na yau da kullun a ranar 7 ga Afrilu.
Kamar balloon, alveoli shine ainihin sashin tsarin huhu. Itace saman alveoli ana kiranta da pulmonary surfactant Layer, wanda ya ƙunshi siriri mai kitse da furotin don kula da alveoli a cikin yanayi mai tsawo. A lokaci guda, wannan membrane na lipid zai iya ware waje daga cikin jiki. Kwayoyin maganin jini, gami da ƙwayoyin rigakafi, ba su da ikon wucewa ta cikin Layer mai aiki da alveolar.
Ko da yake alveolar surfactant Layer ke ware waje daga cikin jiki, tsarin rigakafin mu yana da nau'in phagocytes na musamman, wanda ake kira macrophages. Wadannan macrophages suna shiga cikin alveolar surfactant Layer kuma suna iya phagocytize barbashi da ƙwayoyin cuta da ke cikin iskar da aka shaka, don kiyaye tsabtar alveoli.
"Saboda haka, da zarar COVID-19 ya shiga cikin alveoli, alveolar macrophages suna nannade barbashin kwayar cutar a jikin kwayar halittarsu kuma ya hadiye su a cikin cytoplasm, wanda ke rufe vesicles na kwayar cutar, wanda ake kira endosomes." Huang Bo ya ce, "endosomes na iya isar da kwayoyin cutar zuwa ga lysosomes, tashar zubar da shara a cikin cytoplasm, ta yadda za a iya lalata kwayar cutar zuwa amino acid da nucleotides don sake amfani da kwayar halitta."
Koyaya, COVID-19 na iya amfani da takamaiman yanayin alveolar macrophages don tserewa daga endosomes, sannan kuma amfani da macrophages don kwafin kai.
"A asibiti, ana amfani da bisphosphonates irin su alendronate (AlN) a cikin maganin osteoporosis ta hanyar ƙaddamar da macrophages; magungunan glucocorticoid a matsayin dexamethasone (DEX) maganin hana kumburi ne da aka saba amfani dashi. Huang Bo ya ce mun gano cewa DEX da AlN za su iya toshe kubuta daga kwayar cutar ta hanyar yin niyya ta hanyar CTSL da ƙimar pH na endosomes bi da bi.
Kamar yadda tsarin gudanar da tsarin ke da wuyar samar da shi saboda toshewar shimfidar alveoli da ke sama, Huang Bo ya ce ana samun tasirin irin wannan hadewar ta hanyar feshin hanci kadan. A lokaci guda kuma, wannan haɗin zai iya taka rawar hormone anti-mai kumburi. Wannan maganin feshi mai sauƙi ne, mai aminci, mara tsada da sauƙin haɓakawa. Sabuwar dabara ce don sarrafa farkon kamuwa da COVID-19.