Labarai

Me ya sa fiye da 300 lokuta na m hepatitis na ba a sani ba etiology a cikin fiye da 20 kasashe da yankuna a duniya? Sabon bincike ya nuna cewa yana iya kasancewa yana da alaƙa da super antigen da sabon coronavirus ya haifar. An buga binciken da ke sama a cikin mujallar ilimi mai iko ta duniya "Lancet Gastroenterology & Hepatology".

Binciken da aka ambata ya nuna cewa yaran da suka kamu da sabon coronavirus na iya haifar da samuwar tafkunan ƙwayoyin cuta a cikin jiki. Musamman, kasancewar sabon coronavirus a cikin sashin gastrointestinal na yara na iya haifar da sake sakin sunadaran ƙwayoyin cuta a cikin ƙwayoyin epithelial na hanji, wanda ke haifar da kunna rigakafi. Wannan maimaita kunnawar rigakafi na iya shiga tsakani ta wani babban antigen motif a cikin furotin mai karu na sabon coronavirus, wanda yayi kama da staphylococcal enterotoxin B kuma yana haifar da fa'ida da kunna tantanin halitta T. Wannan super antigen-mediated kunnawa na rigakafi da ƙwayoyin cuta yana da hannu a cikin multisystem kumburi ciwo a cikin yara (MIS-C).

Abin da ake kira Super Antigen (sag) wani irin abu ne wanda zai iya kunna babban adadin ƙwayoyin cuta da ƙarancin taro (≤10 minti). Multisystem kumburi ciwo a cikin yara ya fara samun tartsatsi a hankali tun a watan Afrilu 2020. A lokacin, duniya ta riga ta shiga sabuwar cutar ta kambi, kuma ƙasashe da yawa sun ba da rahoton "bakon cutar yara", wanda ke da alaƙa da sabon kambi. ƙwayar cuta da ake kamuwa. Yawancin marasa lafiya suna fuskantar alamun kamar zazzabi, kurji, amai, kumburin wuyan wuyan lymph nodes, chapped lebe, da gudawa, kwatankwacin na cutar Kawasaki, wanda aka fi sani da cutar Kawasaki. Multisystem kumburi ciwo a cikin yara mafi yawa faruwa 2-6 makonni bayan sabon kambi kamuwa da cuta, da kuma shekaru na farko yara aka mayar da hankali a tsakanin 3-10 shekaru. Ciwon kumburin ƙwayoyin cuta da yawa a cikin yara ya bambanta da cutar Kawasaki, kuma cutar ta fi tsanani a cikin yaran da aka tabbatar da ingancin COVID-19.

Masu binciken sun bincikar cewa cutar hanta na kwanan nan da ba a san dalilin da ya sa yara ba na iya kamuwa da sabon coronavirus da farko, kuma yaran sun kamu da adenovirus bayan tafkin kwayar cutar ya bayyana a cikin hanji.

Masu binciken sun ba da rahoton irin wannan yanayin a cikin gwaje-gwajen linzamin kwamfuta: kamuwa da cuta na Adenovirus yana haifar da staphylococcal enterotoxin B-matsakaicin girgiza mai guba, wanda ke haifar da gazawar hanta da mutuwa a cikin mice. Dangane da halin da ake ciki yanzu, ana ba da shawarar ci gaba da sa ido kan COVID-19 a cikin ɗakin yara masu fama da ciwon hanta. Idan an sami shaidar SARS-CoV-2 mai shiga tsakani na rigakafi na superantigen, yakamata a yi la'akari da maganin immunomodulatory a cikin yara masu tsananin hanta.