Xov xwm

Tau ntsib qhov hloov pauv tsis tu ncua ntawm COVID-19, txoj kev daws teeb meem ib txwm muaj qee qhov tsis zoo.
Xib fwb Huang Bo thiab Qin Chuan pab pawg ntawm CAMS (Suav Academy ntawm Kev Tshawb Fawb Kev Kho Mob) tau tshawb pom tias lub hom phiaj alveolar macrophages yog cov tswv yim zoo rau kev tswj hwm tus kab mob COVID-19 thaum ntxov, thiab pom ob qho tshuaj siv ntau hauv cov qauv ntawm tus nas COVID-19. Cov txiaj ntsig kev tshawb fawb ntsig txog tau tshaj tawm hauv online hauv phau ntawv xov xwm thoob ntiaj teb kev kawm, kev hloov pauv cov teeb liab thiab cov phiaj xwm kho.
"Txoj kev tshawb fawb no tsis yog tsuas yog muab kev nyab xeeb thiab kev kho mob zoo rau COVID-19, tab sis kuj tseem muaj kev sim siab 'siv cov tshuaj qub rau kev siv tshiab', muab txoj hauv kev tshiab ntawm kev xav xaiv cov tshuaj rau COVID-19." Huang Bo tau hais tawm hauv kev xam phaj nrog tus kws tshaj xov xwm ntawm kev tshawb fawb thiab thev naus laus zis txhua hnub Lub Plaub Hlis 7th.
Zoo li lub zais pa, alveoli yog lub hauv paus qauv ntawm lub ntsws. Sab hauv ntawm lub alveoli yog hu ua pulmonary surfactant txheej, uas yog tsim los ntawm ib txheej nyias ntawm cov roj thiab cov protein kom tswj tau cov alveoli nyob rau hauv ib tug ntev lub xeev. Nyob rau tib lub sijhawm, lipid daim nyias nyias tuaj yeem cais tawm sab nraud ntawm sab hauv lub cev. Ntshav tshuaj molecules, nrog rau cov tshuaj tiv thaiv, tsis muaj peev xwm dhau los ntawm alveolar nto active txheej.
Txawm hais tias alveolar surfactant txheej cais tawm sab nraud ntawm sab hauv lub cev, peb lub cev tiv thaiv kab mob muaj cov chav kawm tshwj xeeb phagocytes, hu ua macrophages. Cov macrophages no nkag mus rau alveolar surfactant txheej thiab tuaj yeem phagocytize cov khoom thiab cov kab mob uas muaj nyob hauv cov pa nqus tau pa, txhawm rau tswj kev huv ntawm alveoli.
"Yog li ntawd, ib zaug COVID-19 nkag mus rau alveoli, alveolar macrophages qhwv cov kab mob ntawm lawv cov cell membrane thiab nqos lawv mus rau hauv cytoplasm, uas encapsulate vesicles ntawm tus kab mob, uas yog hu ua endosomes." Huang Bo tau hais tias, "endosomes tuaj yeem xa cov kab mob mus rau lysosomes, qhov chaw pov tseg pov tseg hauv cytoplasm, txhawm rau rhuav tshem tus kab mob mus rau hauv cov amino acids thiab nucleotides rau kev siv ntawm tes.
Txawm li cas los xij, COVID-19 tuaj yeem siv lub xeev tshwj xeeb ntawm alveolar macrophages kom dim ntawm cov endosomes, thiab tig mus siv macrophages rau tus kheej duplication.
"Clinically, bisphosphonates xws li alendronate (AlN) yog siv rau hauv kev kho mob osteoporosis los ntawm kev tsom macrophages; Cov tshuaj glucocorticoid li dexamethasone (DEX) yog ib qho tshuaj tiv thaiv kab mob uas nquag siv. Huang Bo tau hais tias peb pom tias DEX thiab AlN tuaj yeem sib koom ua ke tiv thaiv kev khiav tawm ntawm tus kab mob los ntawm endocytosomes los ntawm kev tsom mus rau kev nthuav qhia ntawm CTSL thiab pH tus nqi ntawm endosomes feem.
Raws li kev tswj hwm lub cev tsis yooj yim los tsim vim muaj kev cuam tshuam ntawm cov txheej txheem ntawm alveoli, Huang Bo tau hais tias cov txiaj ntsig ntawm kev sib xyaw ua ke yog ua tiav los ntawm cov tshuaj tsuag qhov ntswg ib nrab. Nyob rau tib lub sijhawm, qhov kev sib xyaw ua ke no kuj tuaj yeem ua lub luag haujlwm ntawm cov tshuaj hormones tiv thaiv. Cov tshuaj tsuag no yog qhov yooj yim, nyab xeeb, pheej yig thiab yooj yim los txhawb. Nws yog lub tswv yim tshiab rau kev tswj xyuas ntxov ntawm COVID-19 kis.