Akụkọ

N'ịche ihu na COVID-19 na-agbanwe mgbe niile, ụzọ ọdịnala nke ịnagide adịghị adị irè.
Prọfesọ Huang Bo na Qin Chuan otu nke CAMS (Ụlọ Akwụkwọ Academy of Medical Sciences) chọpụtara na alveolar macrophages ezubere iche bụ atụmatụ dị irè maka njikwa mmalite nke ọrịa COVID-19, wee hụ ọgwụ abụọ a na-ejikarị na ụdị òké COVID-19. A na-ebipụta nsonaazụ nyocha dị mkpa na ntanetị na akwụkwọ akụkọ agụmakwụkwọ mba ụwa, ntụgharị mgbaàmà na ọgwụgwọ ezubere iche.
"Ọmụmụ ihe a abụghị naanị na-enye ọgwụgwọ dị mma ma dị mma maka COVID-19, kamakwa ọ na-agba mbọ iji 'iji ọgwụ ochie eme ihe maka ojiji ọhụrụ', na-enye ụzọ echiche ọhụrụ ịhọrọ ọgwụ maka COVID-19." Huang Bo kwusiri ike na N'ajụjụ ọnụ ya na onye nta akụkọ sayensị na teknụzụ kwa ụbọchị na Eprel 7th.
Dị ka balloon, alveoli bụ isi ihe nhazi nke ngụgụ. A na-akpọ elu dị n'ime nke alveoli, oyi akwa surfactant pulmonary, nke nwere obere abụba na protein iji mee ka alveoli dị ogologo. N'otu oge ahụ, akpụkpọ ahụ lipid a nwere ike kewapụ n'èzí n'ime ahụ. Mkpụrụ ndụ ọgwụ ọbara, gụnyere ọgwụ mgbochi ọrịa, enweghị ike ịgafe n'elu alveolar na-arụ ọrụ oyi akwa.
Ọ bụ ezie na oyi akwa surfactant alveolar na-ekewapụ mpụta site n'ime ahụ, usoro ahụ anyị ji alụso ọrịa ọgụ nwere otu klas nke phagocytes pụrụ iche, nke a na-akpọ macrophages. Ndị macrophages ndị a na-abanye n'ime akwa alveolar surfactant ma nwee ike phagocytize ụmụ irighiri ihe na microorganisms dị n'ime ikuku ikuru ume, ka ha wee nọgide na-adị ọcha nke alveoli.
"Ya mere, ozugbo COVID-19 batara na alveoli, macrophages alveolar kechie nje virus n'elu akpụkpọ ahụ ha ma loda ha n'ime cytoplasm, nke na-ekpuchi vesicles nke nje a, nke a na-akpọ endosomes." Huang Bo kwuru, "endosomes nwere ike ibuga nje virus na lysosomes, ebe a na-ekpofu ahịhịa na cytoplasm, iji mebie nje ahụ n'ime amino acids na nucleotides maka iji cell mee ihe."
Agbanyeghị, COVID-19 nwere ike iji ọnọdụ a kapịrị ọnụ nke alveolar macrophages gbanarị na endosomes, ma n'aka nke ya jiri macrophages mee mgharịgharị onwe ya.
"N'ụlọ ọgwụ, a na-eji bisphosphonates dị ka alendronate (AlN) na-agwọ ọrịa osteoporosis site na ịchọta macrophages; ọgwụ glucocorticoid dị ka dexamethasone (DEX) bụ ọgwụ mgbochi mkpali a na-ejikarị. Huang Bo kwuru na anyị chọpụtara na DEX na AlN nwere ike synergistically igbochi ụzọ mgbapụ nke nje si endocytosomes site ezubere iche okwu nke CTSL na pH uru nke endosomes karị.
Dị ka usoro nchịkwa siri ike ịmepụta n'ihi nkwụsị nke elu na-arụ ọrụ oyi akwa nke alveoli, Huang Bo kwuru na a na-enweta mmetụta nke ọgwụgwọ ngwakọta dị otú ahụ site na ịgba imi akụkụ ụfọdụ. N'otu oge ahụ, nchikota a nwekwara ike ịrụ ọrụ nke hormone mgbochi mkpali. Usoro ịgba mmiri a dị mfe, adịghị mma, ọ dịghị ọnụ ma dị mfe ịkwalite. Ọ bụ atụmatụ ọhụrụ maka njikwa mmalite nke ọrịa COVID-19.