Akụkọ

Gịnị kpatara ihe karịrị 300 ikpe nke nnukwu ịba ọcha n'anya nke amaghị etiology na ihe karịrị 20 mba na mpaghara gburugburu ụwa? Nnyocha ọhụrụ gosiri na ọ nwere ike jikọta ya na super antigen nke coronavirus ọhụrụ kpatara. E bipụtara nchoputa ndị a n'elu n'akwụkwọ akụkọ agụmakwụkwọ mba ụwa "Lancet Gastroenterology & Hepatology".

Ihe ọmụmụ ndị a kpọtụrụ aha n'elu egosila na ụmụaka bu ọrịa coronavirus ọhụrụ nwere ike iduga n'ịmepụta ebe nchekwa nje n'ime ahụ. Kpọmkwem, ọnụnọ coronavirus ọhụrụ na-adịgide adịgide na eriri afọ nke ụmụaka nwere ike iduga ntọhapụ nke protein viral ugboro ugboro na sel epithelial intestinal, na-ebute ịgbalite mgbochi. Enwere ike ịgbalite mgbakwasa ọrịa ahụ ugboro ugboro site na nnukwu antigen motif na protein spike nke coronavirus ọhụrụ, nke yiri staphylococcal enterotoxin B ma na-akpalite ịgbalite cell T sara mbara na enweghị nkọwa. Nke a super antigen-mediated gbalite nke mkpụrụ ndụ anaghị alụso ọrịa ọgụ etinyela aka na ọrịa inflammatory multisystem na ụmụaka (MIS-C).

Ihe a na-akpọ super antigen (SAg) bụ ụdị ihe nwere ike mee ka ọnụ ọgụgụ buru ibu nke clones T cell rụọ ọrụ ma mepụta nzaghachi mgbochi siri ike na-enwe naanị ntinye dị ala (≤10-9 M). Multisystem inflammatory syndrome na ụmụaka malitere ịnata nlebara anya zuru oke ka n'isi Eprel 2020. N'oge ahụ, ụwa ka abanyela n'ọgba aghara okpueze ọhụrụ, na ọtụtụ mba ji nke nta nke nta kọọ akụkọ banyere "ọrịa a na-adịghị ahụkebe ụmụaka", bụ nke nwere njikọ chiri anya na okpueze ọhụrụ ahụ. ọfụfe nje. Ọtụtụ ndị ọrịa na-enweta mgbaàmà dị ka ahụ ọkụ, ọkụ ọkụ, ọgbụgbọ, ọzịza n'olu lymph, egbugbere ọnụ gbawara agbawa, na afọ ọsịsa, dị ka nke ọrịa Kawasaki, nke a makwaara dị ka ọrịa Kawasaki. Multisystem inflammatory syndrome na ụmụaka na-emekarị 2-6 izu mgbe ọhụrụ okpueze ọrịa, na afọ nke mmalite ụmụaka na-lekwasị n'etiti 3-10 afọ. Multisystem inflammatory syndrome na ụmụaka dị iche na ọrịa Kawasaki, ọrịa ahụ na-akawanye njọ n'ime ụmụaka ndị na-enyocha ihe dị mma maka COVID-19.

Ndị nyocha ahụ nyochara na nnukwu ịba ọcha n'anya na-adịbeghị anya nke amaghị ihe kpatara ụmụaka nwere ike bu ụzọ bute ọrịa coronavirus ọhụrụ, ụmụaka ahụ butere adenovirus mgbe nchekwa nje pụtara n'ime eriri afọ.

Ndị nchọpụta ahụ na-akọ banyere ọnọdụ yiri nke ahụ na nyocha nke òké: Adenovirus ọrịa na-ebute staphylococcal enterotoxin B-mediated toxic shock, na-eduga na imeju ọdịda na ọnwụ na ụmụ oke. Dabere na ọnọdụ dị ugbu a, a na-atụ aro nyocha COVID-19 na-aga n'ihu na stool ụmụaka nwere nnukwu ịba ọcha n'anya. Ọ bụrụ na achọpụtara ihe akaebe nke SARS-CoV-2 superantigen-mediated ịgbalite mgbochi ọrịa, a ga-atụle ọgwụgwọ immunomodulatory na ụmụaka nwere nnukwu ịba ọcha n'anya.