Amakuru

Guhangana na COVID-19 ihora ihindagurika, uburyo gakondo bwo guhangana nuburyo butari bwiza.
Porofeseri Huang Bo na Qin Chuan bagize itsinda rya CAMS (Ishuri Rikuru ry’Ubuvuzi ry’Ubushinwa) bavumbuye ko macrophage yibasiwe n’ingamba zifatika zo kurwanya hakiri kare kwandura COVID-19, basanga ibiyobyabwenge bibiri bikunze gukoreshwa mu buryo bw’imbeba ya COVID-19. Ibisubizo byubushakashatsi bijyanye bisohoka kumurongo mubinyamakuru mpuzamahanga byigisha, transduction transduction hamwe nubuvuzi bugamije.
Ati: "Ubu bushakashatsi ntabwo butanga ubuvuzi bwiza kandi bunoze kuri COVID-19, ahubwo binagerageza gushira amanga 'gukoresha imiti ishaje kugira ngo ukoreshwe bundi bushya', bitanga uburyo bushya bwo gutekereza guhitamo imiti ya COVID-19.” Ku ya 7 Mata, Huang Bo yashimangiye mu kiganiro n’umunyamakuru wa siyansi n’ikoranabuhanga buri munsi.
Kimwe na ballon, alveoli nigice cyibanze cyimiterere yibihaha. Ubuso bwimbere bwa alveoli bwitwa pulmonary surfactant layer, igizwe nurwego ruto rwamavuta na proteyine kugirango ibungabunge alveoli muburyo bwagutse. Mugihe kimwe, iyi lipide membrane irashobora gutandukanya hanze imbere mumubiri. Molekile yibiyobyabwenge byamaraso, harimo na antibodies, ntabwo ifite ubushobozi bwo kunyura hejuru ya alveolar igaragara.
Nubwo alveolar surfactant layer itandukanya hanze imbere yumubiri, sisitemu yumubiri yacu ifite icyiciro cya fagocytes yihariye, yitwa macrophage. Izi macrophage zinjira muri alveolar surfactant layer kandi zirashobora kwangiza fagocytize ibice na mikorobe bikubiye mu mwuka uhumeka, kugirango bikomeze kugira isuku ya alveoli.
Ati: "Kubwibyo, COVID-19 imaze kwinjira muri alveoli, macrophage ya alveolar ipfunyika uduce duto twa virusi hejuru ya selile hanyuma ikayimira muri cytoplazme, ikubiyemo imitsi ya virusi, bita endosomes." Huang Bo yagize ati: “endosomes irashobora kugeza virusi ya lysosomes, sitasiyo yo guta imyanda muri cytoplazme, kugira ngo yanduze virusi muri aside amine na nucleotide kugira ngo yongere gukoreshwa.”
Nyamara, COVID-19 irashobora gukoresha imiterere yihariye ya macrophage ya alveolar kugirango ihunge endosomes, hanyuma nayo ikoreshe macrophage kugirango yigane.
“Mubuvuzi, bisphosifone nka alendronate (AlN) ikoreshwa mu kuvura osteoporose yibasira macrophage; ibiyobyabwenge bya glucocorticoid nka dexamethasone (DEX) niwo muti ukunze gukoreshwa mu kurwanya indwara. ” Huang Bo yavuze ko twasanze DEX na AlN zishobora guhuriza hamwe guhagarika virusi ya endocytosomes mu kwerekana imvugo ya CTSL hamwe n’agaciro ka pH ka endosomes.
Kubera ko imiyoborere itoroshye kuyibyaza umusaruro bitewe no kubangamira ubuso bukora bwa alveoli, Huang Bo yavuze ko ingaruka zo kuvura ubwo buryo zigerwaho binyuze mu gutera izuru igice. Mugihe kimwe, uku guhuza kurashobora kandi kugira uruhare mumisemburo irwanya inflammatory. Ubu buryo bwo kuvura spray buroroshye, butekanye, buhendutse kandi bworoshye kuzamura. Nuburyo bushya bwo kurwanya hakiri kare kwandura COVID-19.