Amakuru

Niki cyateye abantu barenga 300 barwaye hepatite ikaze ya etiologiya itazwi mu bihugu n'uturere birenga 20 ku isi? Ubushakashatsi buheruka kwerekana bwerekana ko bushobora kuba bufitanye isano na super antigen yatewe na coronavirus nshya. Ibyavuzwe haruguru byasohotse mu kinyamakuru mpuzamahanga cyemewe cy’amasomo “The Lancet Gastroenterology & Hepatology”.

Ubushakashatsi bumaze kuvugwa bwerekanye ko abana banduye coronavirus nshya bashobora gutuma habaho ibigega bya virusi mu mubiri. By'umwihariko, guhora kwa coronavirus nshya mu nzira ya gastrointestinal y'abana birashobora gutuma poroteyine zandura kenshi mu ngirabuzimafatizo zo mu nda, bikaviramo gukora ubudahangarwa bw'umubiri. Uku gukingira indwara kwinshi gushobora guhuzwa na super antigen motif muri spike proteine ​​ya coronavirus nshya, isa na staphylococcal enterotoxine B kandi igatera gukora selile nini kandi idafite akamaro. Iyi super antigen-medrated mediation ya selile yumubiri yagize uruhare muri syndrome ya sisitemu nyinshi yibasira abana (MIS-C).

Ibyo bita super antigen (SAg) ni ubwoko bwibintu bishobora gukora clone nyinshi ya T selile kandi bikabyara ubudahangarwa bukomeye hamwe nubushakashatsi buke cyane (≤10-9 M). Indwara ya syndrome ya Multisystem mu bana yatangiye kwitabwaho cyane guhera muri Mata 2020. Muri icyo gihe, isi yari imaze kwinjira mu cyorezo gishya cy’ikamba, kandi ibihugu byinshi byagiye bivugako “indwara idasanzwe y’abana”, yari ifitanye isano cyane n’ikamba rishya. kwandura virusi. Abenshi mu barwayi bagaragaza ibimenyetso nk'umuriro, guhubuka, kuruka, kubyimba lymph node, kubyimba iminwa, no gucibwamo, bisa n'iby'indwara ya Kawasaki, izwi kandi ku ndwara ya Kawasaki. Indwara ya syndrome ya Multisystem yibana cyane cyane ibaho nyuma y'ibyumweru 2-6 nyuma yo kwandura ikamba rishya, kandi imyaka y'abana itangira iba hagati yimyaka 3-10. Indwara ya syndrome ya Multisystem mu bana itandukanye n'indwara ya Kawasaki, kandi indwara irakabije cyane ku bana bafite serosurveile nziza kuri COVID-19.

Abashakashatsi basesenguye ko hepatite ikaze y’impamvu itazwi ku bana ishobora kuba yaranduye coronavirus nshya, kandi abana banduye adenovirus nyuma yuko ikigega cya virusi kigaragaye mu mara.

Abashakashatsi bavuga ko ibintu bimeze nk'ibyo mu bushakashatsi bw’imbeba: Indwara ya Adenovirus itera staphylococcal enterotoxin B-yatewe n'uburozi bw’ubumara, bigatuma umwijima unanirwa no gupfa ku mbeba. Ukurikije uko ibintu bimeze ubu, birasabwa ko hakomeza gukurikiranwa COVID-19 mu ntebe y’abana barwaye hepatite ikaze. Niba habonetse ibimenyetso bya SARS-CoV-2 superantigen-yunganiwe no gukingira indwara, hagomba gusuzumwa imiti ikingira abana bafite hepatite ikaze.