Kutarisana neiyo inogara ichichinja COVID-19, nzira dzechinyakare dzekugadzirisa hadzina kushanda.
Muzvinafundo Huang Bo naQin Chuan timu yeCAMS (Chinese Academy of Medical Sayenzi) vakawana kuti yakanangwa alveolar macrophages yaive nzira dzinoshanda dzekudzora hutachiona hweCCIDID-19, uye vakawana mishonga miviri inowanzoshandiswa muCOVID-19 modhi. Mhedzisiro yetsvagiridzo yakakodzera inoburitswa online mujenari redzidzo yepasirese, kutapurirana kwechiratidzo uye kurapwa kwakanangwa.
"Chidzidzo ichi hachingopi kurapa kwakachengeteka uye kunoshanda kweCCIDID-19, asiwo kuedza kwakashinga 'kushandisa mishonga yekare kushandiswa patsva', ichipa nzira itsva yekufunga yekusarudza mishonga yeCOVID-19." Huang Bo akasimbisa mubvunzurudzo nemutori wenhau wesainzi uye tekinoroji zuva nezuva Musi wa7 Kubvumbi.
Kufanana nebharumu, alveoli ndiyo yakakosha dhizaini yemapapu. Nzvimbo yemukati yealveoli inonzi pulmonary surfactant layer, iyo inoumbwa nehutete hwakatsetseka hwemafuta uye mapuroteni kuchengetedza alveoli mune imwe nguva yakareba. Panguva imwecheteyo, iyi lipid membrane inogona kuparadzanisa kunze kubva mukati memuviri. Mamorekuru emishonga yeropa, kusanganisira masoja ekudzivirira chirwere, haana simba rekupfuura nepakati pealveolar surface active layer.
Kunyangwe iyo alveolar surfactant layer ichiparadzanisa kunze kubva mukati memuviri, immune system yedu ine kirasi yehunyanzvi phagocytes, inonzi macrophages. Aya macrophages anopinda mualveolar surfactant layer uye anogona phagocytize zvidimbu uye microorganisms zviri mumhepo inofema, kuitira kuchengetedza kuchena kwealveoli.
"Nekudaro, kana COVID-19 yapinda mualveoli, alveolar macrophages inoputira hutachiona pasero membrane uye ichimedza mucytoplasm, iyo inovhara mavhesi ehutachiona, anonzi endosomes." Huang Bo akati, "maendosomes anogona kuendesa hutachiona kune lysosomes, nzvimbo yekurasa tsvina mucytoplasm, kuitira kuti iparadze hutachiona muamino acids uye nucleotides kuti ishandisezve sero."
Nekudaro, COVID-19 inogona kushandisa iyo chaiyo mamiriro ealveolar macrophages kutiza kubva kune endosomes, uyezve kushandisa macrophages kuzvidzokorora.
“Kuchipatara, ma<em>bisphosphonates akadai sealendronate (AlN) anoshandiswa mukurapa osteoporosis nekutarisa macrophages; mushonga weglucocorticoid sedexamethasone (DEX) mushonga unowanzoshandiswa unorwisa kuzvimba.” Huang Bo akataura kuti takaona kuti DEX neAlN zvinogona kuvharisa kupukunyuka kwehutachiona kubva endocytosomes nekunanga kutaura kweCTSL uye pH kukosha kweendosomes zvichiteerana.
Sezvo systemic manejimendi yakaoma kuburitsa nekuda kwekuvharika kweiyo nzvimbo inoshanda yealveoli, Huang Bo akataura kuti mhedzisiro yekurapa kwakadai kunowanikwa kuburikidza nemhino yekupfapfaidza chikamu. Panguva imwecheteyo, kusanganiswa uku kunogonawo kutamba basa rehomoni inopesana nekuputika. Iyi spray therapy iri nyore, yakachengeteka, isingadhure uye iri nyore kusimudzira. Iri izano idzva rekudzora kwekutanga kwehutachiona hweCCIDID-19.
Nguva yekutumira: Kubvumbi-15-2022