Chii chakakonzera zvinopfuura mazana matatu ezviitiko zveacute hepatitis yezvisingazivikanwi etiology munyika dzinopfuura makumi maviri nematunhu pasi rose? Tsvagiridzo yazvino inoratidza kuti inogona kunge ine hukama neiyo super antigen yakakonzerwa neiyo coronavirus nyowani. Zvakawanikwa pamusoro zvakaburitswa mugwaro redzidzo repasi rose re “The Lancet Gastroenterology & Hepatology”.
Zvidzidzo zvambotaurwa zvakaratidza kuti vana vanotapukirwa nekoronavirus nyowani vanogona kutungamira mukuumbwa kwematanho ehutachiona mumuviri. Kunyanya, kuenderera mberi kwekuvapo kweiyo coronavirus nyowani mudumbu revana kunogona kutungamira mukuburitswa kwehutachiona mapuroteni mumatumbo epithelial masero, zvichikonzera immune activation. Uku kudzokororwa kwekudzivirira immune activation kunogona kuyananiswa neiyo super antigen motif mu spike protein yekoronavirus itsva, yakafanana ne staphylococcal enterotoxin B uye inokonzeresa yakafara uye isina specific T cell activation. Iyi yepamusoro-antigen-mediated activation yemasero ekudzivirira yakave yakabatanidzwa mumultisystem inflammatory syndrome muvana (MIS-C).
Iyo inodaidzwa kuti super antigen (SAg) imhando yezvinhu inogona kumisa nhamba huru yeT cell clones uye kuburitsa yakasimba immune system nekungodzika kwakadzikira (≤10-9 M). Multisystem inflammatory syndrome muvana yakatanga kugamuchira kutarisisa kwakapararira kutanga kwaApril 2020. Panguva iyoyo, nyika yakanga ichangopinda mudenda idzva rekorona, uye nyika zhinji dzakatevedzana dzakarondedzera "chirwere chinoshamisa chevana", icho chaive chakabatana zvakanyanya nekorona nyowani. urwere hwakonzerwa neutachiona. Varwere vazhinji vanoona zviratidzo zvakaita sefivha, mapundu, kurutsa, kuzvimba mutsipa lymph nodes, miromo yakatsemuka, uye manyoka, zvakafanana neaya echirwere cheKawasaki, chinozivikanwawo sechirwere cheKawasaki. Multisystem inflammatory syndrome muvana inowanzoitika mavhiki e2-6 mushure mekutapukirwa kwekorona itsva, uye zera rekutanga vana rinonyanya pakati pemakore 3-10. Multisystem inflammatory syndrome muvana yakasiyana nechirwere cheKawasaki, uye chirwere ichi chakanyanya muvana vanotariswa vaine COVID-19.
Vatsvagiri vakaongorora kuti ichangoburwa hepatitis yeisingazivikanwe chikonzero muvana inogona kunge yakatapukirwa neiyo coronavirus nyowani, uye vana vakatapukirwa neadenovirus mushure mekuonekwa kwehutachiona muura.
Vatsvagiri vanoshuma mamiriro akafanana mukuyedza mbeva: Utachiona hweAdenovirus hunokonzeresa staphylococcal enterotoxin B-mediated toxic shock, zvichikonzera kutadza kwechiropa uye kufa mumakonzo. Zvichienderana nemamiriro ezvinhu aripo, kuenderera mberi kweCCIDID-19 kuongororwa kunokurudzirwa muchigaro chevana vane acute hepatitis. Kana humbowo hweSARS-CoV-2 superantigen-mediated immune activation hunowanikwa, immunomodulatory therapy inofanirwa kutariswa muvana vane yakanyanya acute hepatitis.
Nguva yekutumira: May-21-2022