Wararka

Iyadoo loo wajahayo COVID-19 oo is beddelaya, siyaabaha soo jireenka ah ee lagula tacaali karo ayaa ah kuwo aan waxtar lahayn.
Professor Huang Bo iyo kooxda Qin Chuan ee CAMS (Akadamiyadda Sayniska Caafimaadka ee Shiinaha) waxay ogaadeen in macrophages alveolar ee la beegsaday ay ahaayeen xeelado wax ku ool ah oo lagu xakameynayo goor hore ee caabuqa COVID-19, waxayna heleen laba daawo oo caadi ahaan loo isticmaalo moodelka COVID-19. Natiijooyinka cilmi-baarista ee laxidhiidha waxaa lagu daabacay khadka internetka joornaalka tacliinta caalamiga ah, gudbinta calaamadaha iyo daawaynta la beegsaday.
"Daraasaddani kaliya kuma siinayso daaweyn badbaado leh oo waxtar leh COVID-19, laakiin sidoo kale isku day geesinimo leh oo 'daawooyinkii hore loogu isticmaalo isticmaalka cusub', taasoo bixisa hab cusub oo lagu fakarayo oo lagu dooranayo dawooyinka COVID-19." Huang Bo waxa uu ku nuuxnuuxsaday waraysi uu siiyay wariyaha maalinlaha ah ee sayniska iyo tignoolajiyada Abriil 7-deedii.
Sida buufin, alveoli waa unugga qaab dhismeedka aasaasiga ah ee sambabada. Dusha sare ee alveoli waxaa loo yaqaan lakabka surfactant sambabada, kaas oo ka kooban lakab khafiif ah oo dufan iyo borotiin ah si loo ilaaliyo alveoli xaalad fidsan. Isla mar ahaantaana, xuubka dufanku wuxuu ka sooci karaa bannaanka gudaha jidhka. Unugyada daawada dhiigga, oo ay ku jiraan unugyada difaaca jirka, ma laha awood ay ku dhex maraan lakabka firfircoon ee dusha alveolar.
Inkasta oo lakabka surfactant alveolar uu dibadda ka soocay gudaha jidhka, habka difaacayagu waxa uu leeyahay nooc ka mid ah phagocytes gaar ah, oo loo yaqaan macrophages. Makrophages-yadani waxay galaan lakabka surfactant alveolar waxayna phagocytize karaan qaybaha iyo microorganismsyada ku jira hawada la nuugo, si loo ilaaliyo nadaafadda alveoli.
"Sidaas darteed, mar haddii COVID-19 uu galo alveoli, alveolar macrophages waxay ku duubaan qaybaha fayraska ee xuubka unugga oo ay ku liqaan cytoplasm, kaas oo daboolaya unugyada fayraska, oo loo yaqaanno endosomes." Huang Bo wuxuu yiri, "endosomes waxay gaarsiin karaan qaybo fayraska lysosomes, oo ah xarun qashinka lagu tuuro cytoplasm, si ay u kala gooyaan fayraska amino acids iyo nucleotides si dib loogu isticmaalo unugyada."
Si kastaba ha noqotee, COVID-19 wuxuu isticmaali karaa xaaladda gaarka ah ee macrophages alveolar si uu uga baxsado endosomes, oo uu beddelkeeda isticmaalo makrophages si uu iskiis isu rogo.
"Clinik ahaan, bisfosphonates sida alendronate (AlN) waxaa loo isticmaalaa daaweynta lafo-jileecu iyada oo la beegsanayo macrophages; dawada glucocorticoid sida dexamethasone (DEX) waa daawo caadi ah oo la isticmaalo ka hortagga bararka." Huang Bo waxa uu sheegay in aanu ogaanay in DEX iyo AlN ay si isku mid ah u xannibi karaan ka baxsiga fayraska ee endocytosomes iyada oo la beegsanayo muujinta CTSL iyo qiimaha pH ee endosomes siday u kala horreeyaan.
Maaddaama maamulka nidaamku ay adag tahay in la soo saaro sababtoo ah xannibaadda dusha sare ee lakabka firfircoon ee alveoli, Huang Bo wuxuu sheegay in saameynta daaweynta isku dhafan ee noocan oo kale ah lagu gaaro buufin sanka qayb ahaan. Isla mar ahaantaana, isku-dhafkan ayaa sidoo kale ka ciyaari kara doorka hormoonka anti-bararka. Daawaynta buufintan waa mid fudud, badbaado leh, raqiis ah oo fudud in la dhiirrigeliyo. Waa xeelad cusub oo lagu xakameynayo goor hore ee caabuqa COVID-19.