Maxaa sababay in ka badan 300 xaaladood oo cagaarshow ba'an oo aan la garanayn etiology ee in ka badan 20 waddan iyo gobollada adduunka oo dhan? Cilmi-baaristii ugu dambeysay waxay muujineysaa in laga yaabo inay la xiriirto antigen-ka super ee uu keeno coronavirus-ka cusub. Natiijooyinka kor ku xusan waxaa lagu daabacay joornaalka tacliineed ee caalamiga ah "Lancet Gastroenterology & Hepatology".
Daraasadaha aan soo sheegnay ayaa muujiyay in carruurta uu ku dhacay cudurka 'coronavirus' cusub ay horseedi karaan samaynta kaydka fayraska ee jirka. Gaar ahaan, joogitaanka joogtada ah ee coronavirus-ka cusub ee mareenka caloosha iyo mindhicirka ee carruurta waxay horseedi kartaa sii daynta borotiinnada fayraska ee soo noqnoqda ee unugyada epithelial xiidmaha, taasoo keenta firfircoonida difaaca. Dhaqdhaqaaqa difaaca jirka ee soo noqnoqda waxaa dhexdhexaadin kara motif super antigen oo ku jira borotiinka sare ee coronavirus-ka cusub, kaas oo la mid ah staphylococcal enterotoxin B oo kiciya firfircoonida unugga T ballaaran oo aan gaar ahayn. Dhaqdhaqaaqa super antigen-dhexdhexaadin ee unugyada difaaca ayaa lagu lug yeeshay xanuunka caabuqa ee nidaamka badan ee carruurta (MIS-C).
Waxa loogu yeero super antigen (SAg) waa nooc ka mid ah walaxda firfircooni karta tiro badan oo ah unugyada T-yada oo dhalin kara jawaab difaac adag oo leh oo kaliya feejignaan aad u hooseeya (≤10-9 M). Cudurka caabuqa ee nidaamka kala duwan ee carruurta ayaa bilaabay inuu helo fiiro gaar ah horaantii Abriil 2020. Waqtigaas, dunidu waxay soo gashay cudurka faafa ee taajka cusub, dalal badanna waxay si isdaba joog ah u soo sheegeen "cudur la yaab leh oo carruurta", kaas oo si weyn ula xiriiray taajka cusub. caabuqa fayruuska. Bukaanjiifka badankoodu waxay la kulmaan calaamado ay ka mid yihiin qandho, finan, matag, qanjidhada qoorta oo barara, bushimaha jeexan, iyo shuban, oo la mid ah kuwa cudurka Kawasaki, oo sidoo kale loo yaqaanno Kawasaki-u eg. Cudurka caabuqa ee nidaamka kala duwan ee carruurta wuxuu badanaa dhacaa 2-6 toddobaad ka dib caabuqa taajka cusub, da'da carruurta bilawga ah waxay ku urursan tahay inta u dhaxaysa 3-10 sano. Cudurka caabuqa ee nidaamka kala-duwan ee carruurta waa uu ka duwan yahay cudurka Kawasaki, oo cudurku aad ayuu ugu daran yahay carruurta laga baaray cudurka COVID-19.
Cilmi-baadhayaashu waxay falanqeeyeen in cagaarshow ba'an ee dhowaan aan la garanayn sababta carruurta laga yaabo in uu ku dhacay cudurka 'coronavirus' cusub marka hore, carruurtana waxaa ku dhacay adenovirus ka dib markii kaydka fayrasku ka soo muuqday mindhicirka.
Cilmi-baadhayaashu waxay ka warbixiyaan xaalad la mid ah tijaabooyinka jiirka: Caabuqa Adenovirus wuxuu kiciyaa staphylococcal enterotoxin B-dhexdhexaad ah shoog sun ah, taasoo keenta beer-la'aanta iyo dhimashada jiirarka. Iyada oo ku saleysan xaaladda hadda jirta, ilaalinta COVID-19 ee socota ayaa lagula talinayaa saxarada carruurta qabta cagaarshow ba'an. Haddii la helo caddaynta firfircoonida difaaca jirka ee dhexdhexaadka ah ee SARS-CoV-2, daawaynta difaaca jirka waa in lagu qaddariyo carruurta qaba cagaarshow ba'an.
Waqtiga boostada: May-21-2022