Utyando Sutures
I-Sutures ye-Sutures ibalulekile ekuvaleni amanxeba, amandla okwenza amandla amakhulu kune-adhesives ye-tissue kunye nokukhawulezisa inkqubo yokuphilisa yendalo. Zininzi izixhobo zotyando lwe-suture ezamkelwe le njongo-ezinje ngeeplastiki ezingonakalayo nezingonakaliyo, iiproteni eziphuma kwibhayoloji, kunye neentsimbi - kodwa ukusebenza kwazo kuthintelwe kukuqina kwazo. Izinto eziqhelekileyo ze-suture zingabangela ukungahambi kakuhle, ukuvuvukala kunye nokuphazamiseka kokuphilisa, phakathi kwezinye iingxaki emva kokuhlinzwa.
Kwiinzame zokulungisa le ngxaki, abaphandi abavela eMontreal baye baphuhlisa ijeli eqinileyo ye-sheath (TGS) i-sutures yokuhlinzwa ephefumlelwe ngumthambo womntu.
Ezi sutures zesizukulwana esilandelayo ziqulethe imvulophu yejeli emtyibilizi, kodwa eyomeleleyo, ilinganisa ukwakheka kwezicubu ezithambileyo ezidibeneyo. Ekubekeni ijeli eqinileyo (i-TGS) yotyando lwe-sutures kuvavanyo, abaphandi bafumanise ukuba umphezulu wejeli ophantse wakhubana uthomalalise umonakalo obangelwa ziisutures zesintu.
Iisutures eziqhelekileyo zotyando ziye zajikeleza iinkulungwane kwaye zisetyenziselwa ukubamba amanxeba kunye de inkqubo yokuphilisa iphelile. Kodwa zikude ukuba zilungele ukulungiswa kwezicubu. Iintsinga ezirhabaxa ziyakwazi ukusika kwaye zonakalise izicubu ezisele zibuthathaka, nto leyo ekhokelela ekungakhululekiyo kunye neengxaki zasemva kotyando.
Ngokutsho kwabaphandi, inxalenye yengxaki nge-sutures eqhelekileyo kukungafani phakathi kwezicubu zethu ezithambileyo kunye nokuqina kwee-sutures ezixubha ngokuchasene nezicubu. IYunivesithi yaseMcGill kunye neqela leZiko loPhando le-INRS Énergie Matériaux Télécommunications liye lajongana nale ngxaki ngokuphuhlisa itekhnoloji entsha elinganisa ubuchwephesha beetendon.
Iphefumlelwe yi-Tendons yoMntu
Ukujongana nale ngxaki, iqela lenze iteknoloji entsha elinganisa i-mechanics ye-tendon. “Uyilo lwethu luphefumlelwe ngumzimba womntu, i-endotenon sheath, eyomeleleyo kwaye yomelele ngenxa yolwakhiwo lwenethiwekhi ephindwe kabini.
Ibophelela imicu ye-collagen kunye ngelixa inethiwekhi yayo ye-elastin iyomeleza, "utsho umbhali okhokelayo uZhenwei Ma, umfundi we-PhD phantsi kweliso likaNjingalwazi oNcedisayo uJianyu Li kwiYunivesithi yaseMcGill.
I-endotenon sheath yenza indawo emtyibilizi yokunciphisa ingxabano kunye nezicubu ezijikelezileyo kwaye ihambisa izinto zokulungiswa kwezicubu kumonzakalo we-tendon, oquka iiseli kunye nemithambo yegazi kunye nokuthuthwa ngobuninzi kunye nokulungiswa kwe-tendon.
Ijeli eqinileyo eneshefu (i-TGS) i-sutures yotyando inokwenziwa ukuba ibonelele ngeyeza lomntu ngokusekwe kwiimfuno zesigulana, batsho abaphandi.
Isizukulwana esilandelayo Suture Materials
Iisutu zeYunivesithi yaseMcGill ziqulethe i-suture edumileyo yorhwebo ephothiweyo ngaphakathi kwemvulophu yejeli elinganisa esi singxobo. Ijeli eqinileyo ene sheathed (TGS) sutures yotyando inokwenziwa ukuya kuthi ga kwi-15cm ubude kwaye inokomiswa ukuze igcinwe ixesha elide.
Besebenzisa kuqala ulusu lweporcine emva koko imodeli yeempuku, abaphandi babonise ukuba banokusetyenziselwa izithungo eziqhelekileyo zotyando kunye namaqhina kwaye bayasebenza ekuvaleni amanxeba ngaphandle kokubangela usulelo.
Ijeli eqinileyo eneshefu (i-TGS) i-sutures yotyando - kwenye ingqamaniso kunye ne-endotenon sheaths - ingaphinda iyilwe ukunika unyango lwenxeba lomntu.
Unyango Lwenxeba Olulolwakho
Abaphandi babonise lo mgaqo ngokulayisha i-sutures kunye ne-antibacterial compound, i-pH ibona i-microparticles, iziyobisi kunye ne-fluorescent nanoparticles yokuchasana ne-infection, ukubeka iliso kwibhedi yesilonda, ukuhanjiswa kweziyobisi kunye nezicelo ze-bioimaging.
“Obu bugcisa bubonelela ngesixhobo esiguquguqukayo solawulo lwamanxeba oluphezulu. Sikholelwa ukuba inokusetyenziswa ukuhambisa iziyobisi, ukuthintela usulelo, okanye nokubeka iliso kumanxeba ngemifanekiso ekufuphi ne-infrared,” utsho uLi weSebe lobuNjineli boomatshini.
"Amandla okubeka iliso kumanxeba kwindawo kwaye ulungelelanise isicwangciso sonyango sokuphulukiswa okungcono yindlela enomdla yokuphonononga," utshilo uLi, onguSihlalo woPhando waseCanada kwi-Biomaterials kunye ne-Musculoskeletal Health.
Izingqinisiso eziphambili:
1. IYunivesithi yaseMcGill
2. I-Bioinspired i-sheath yejeli eqinile yokuqina kunye nokusebenza okuguquguqukayo komphezulu. Zhenwei Ma et. al. Ukuqhubela phambili kwezeNzululwazi, ngo-2021; 7 (15): eabc3012 DOI: 10.1126/sciadv.abc3012
Ixesha lokuposa: Apr-02-2022