Yintoni eyabangela iimeko ezingaphezu kwe-300 ze-hepatitis eyingozi ye-etiology engaziwayo kumazwe angaphezu kwama-20 kunye nemimandla emhlabeni jikelele? Uphando lwamva nje lubonisa ukuba inokunxulumana ne-antigen enkulu ebangelwa yi-coronavirus entsha. Oku kufunyenwe ngasentla kupapashwe kwijenali yezemfundo egunyazisiweyo yamazwe ngamazwe "I-Lancet Gastroenterology & Hepatology".
Uphononongo olukhankanywe ngasentla lubonise ukuba abantwana abosulelwe yi-coronavirus entsha banokukhokelela ekwakhiweni kwamadama entsholongwane emzimbeni. Ngokukodwa, ubukho obuzingisileyo be-coronavirus entsha kwindlela yesisu yabantwana kunokukhokelela ekukhululweni okuphindaphindiweyo kweeprotheni zentsholongwane kwiiseli ze-epithelial zamathumbu, okukhokelela ekusebenzeni kokuzivikela komzimba. Oku kuphinda kusebenze amajoni omzimba kunokuba lamlwa yi-super antigen motif kwiprotein ye-spike ye-coronavirus entsha, efana ne-staphylococcal enterotoxin B kwaye ibangele ukusebenza kweseli ye-T ebanzi kunye nengacacisiweyo. Oku kusebenze okuphezulu kwe-antigen-mediated yeeseli zomzimba kuye kwabandakanyeka kwi-multisystem inflammatory syndrome kubantwana (MIS-C).
Into ebizwa ngokuba yi-super antigen (i-SAg) luhlobo lwento enokuthi isebenze inani elikhulu le-T cell clones kwaye ivelise impendulo eqinile ye-immune kunye noxinzelelo oluphantsi kakhulu (≤10-9 M). I-Multisystem inflammatory syndrome ebantwaneni yaqala ukufumana ingqwalasela ebanzi kwangoko ngo-Epreli ka-2020. Ngelo xesha, ihlabathi lalisandula ukungena kwisithsaba esitsha, kwaye amazwe amaninzi achaza ngokulandelelana "isifo esingaqhelekanga sabantwana", esasinxulumene kakhulu nesithsaba esitsha. usuleleko lwentsholongwane. Uninzi lwezigulana zifumana iimpawu ezinjengomkhuhlane, irhashalala, ukugabha, ukudumba kwentamo ilymph nodes, imilebe echophileyo, kunye norhudo, ezifanayo nezo zesifo sikaKawasaki, esikwabizwa ngokuba sisifo seKawasaki. I-Multisystem inflammatory syndrome kubantwana idla ngokuvela kwiiveki ezi-2-6 emva kosulelo olutsha lwesithsaba, kwaye ubudala bomntwana wokuqala bugxininiswe phakathi kwe-3-10 ubudala. I-Multisystem inflammatory syndrome ebantwaneni yahlukile kwisifo se-Kawasaki, kwaye isifo siqatha ngakumbi kubantwana abafunyenwe bene-COVID-19.
Abaphandi bahlalutya ukuba i-hepatitis yamva nje yesizathu esingaziwayo ebantwaneni inokosulelwa yi-coronavirus entsha kuqala, kwaye abantwana bosulelwa yi-adenovirus emva kokuvela kwentsholongwane emathunjini.
Abaphandi baxela imeko efanayo kwiimvavanyo zegundane: Usulelo lwe-Adenovirus lubangela i-staphylococcal enterotoxin B-mediated shock shock, ekhokelela ekungaphumeleli kwesibindi kunye nokufa kwiimpuku. Ngokusekwe kwimeko yangoku, uphononongo oluqhubekayo lwe-COVID-19 luyacetyiswa kwisitulo sabantwana abane-hepatitis ebukhali. Ukuba ubungqina be-SARS-CoV-2 superantigen-mediated immune activation bufunyenwe, unyango lwe-immunomodulatory kufuneka luthathelwe ingqalelo kubantwana abane-hepatitis ebukhali.
Ixesha lokuposa: May-21-2022