Sibhekene ne-COVID-19 ehlala ishintsha, izindlela zendabuko zokubhekana nazo azisebenzi ngandlela thile.
USolwazi u-Huang Bo kanye nethimba le-Qin Chuan le-CAMS(Chinese Academy of Medical Sciences) bathole ukuthi ama-alveolar macrophages okuhlosiwe ayengamaqhinga asebenzayo okulawula kusenesikhathi ukutheleleka nge-COVID-19, futhi bathola izidakamizwa ezimbili ezivame ukusetshenziswa kumodeli yegundane ye-COVID-19. Imiphumela yocwaningo efanelekile ishicilelwa ku-inthanethi kujenali yezemfundo yamazwe ngamazwe, ukudluliswa kwezimpawu kanye nokwelashwa okuqondiwe.
"Lolu cwaningo aluhlinzeki nje kuphela ngokwelashwa okuphephile nokusebenzayo kwe-COVID-19, kodwa futhi nomzamo wesibindi 'wokusebenzisa izidakamizwa ezindala ukuze zisetshenziswe okusha', okuhlinzeka ngendlela entsha yokucabanga yokukhetha izidakamizwa ze-COVID-19." U-Huang Bo ugcizelele engxoxweni nentatheli yesayensi nobuchwepheshe nsuku zonke Ngo-Ephreli 7.
Njengebhaluni, i-alveoli iyiyunithi eyisisekelo yesakhiwo sephaphu. Ingaphakathi le-alveoli libizwa ngokuthi ungqimba lwe-pulmonary surfactant, olwakhiwe ungqimba oluncane lwamafutha namaprotheni ukuze kugcinwe i-alveoli esimweni esinwetshiwe. Ngesikhathi esifanayo, le membrane ye-lipid ingahlukanisa ingaphandle ngaphakathi komzimba. Ama-molecule emithi yegazi, okuhlanganisa amasosha omzimba, awanawo amandla okudlula ungqimba olusebenzayo lwe-alveolar.
Nakuba ungqimba lwe-alveolar surfactant luhlukanisa ingaphandle nengaphakathi lomzimba, isimiso sethu somzimba sokuzivikela ezifweni sinesigaba sama-phagocyte akhethekile, abizwa ngokuthi ama-macrophage. Lawa ma-macrophage angena kungqimba lwe-alveolar surfactant futhi angaphagocytize izinhlayiya nama-microorganisms aqukethwe emoyeni ohogeliwe, ukuze alondoloze ukuhlanzeka kwe-alveoli.
"Ngakho-ke, uma i-COVID-19 ingena ku-alveoli, ama-alveolar macrophages asonga izinhlayiya zegciwane kulwelwesi lwamaseli angaphezulu bese liwagwinya ku-cytoplasm, ehlanganisa ama-vesicles aleli gciwane, abizwa ngokuthi ama-endosomes." U-Huang Bo uthe, "ama-endosomes angaletha izinhlayiya zegciwane kuma-lysosomes, isiteshi sokulahla imfucuza ku-cytoplasm, ukuze abolise leli gciwane libe ama-amino acid nama-nucleotide ukuze lisetshenziswe kabusha iseli."
Kodwa-ke, i-COVID-19 ingasebenzisa isimo esithile se-alveolar macrophage ukuze ibaleke kuma-endosomes, bese isebenzise ama-macrophage ukuze iziphindiselele.
“Emtholampilo, ama-bisphosphonates afana ne-alendronate (AlN) asetshenziswa ekwelapheni i-osteoporosis ngokukhomba ama-macrophages; isidakamizwa se-glucocorticoid njenge-dexamethasone (DEX) iyisidakamizwa esivame ukusetshenziswa eqeda ukuvuvukala.” U-Huang Bo uthe sithole ukuthi i-DEX ne-AlN zingavimba ngokuhlanganyela ukuphuma kwegciwane kuma-endocytosomes ngokukhomba ukuvezwa kwe-CTSL kanye nenani le-pH lama-endosomes ngokulandelana.
Njengoba ukuphatha okuhlelekile kunzima ukukhiqiza ngenxa yokuvinjwa kongqimba olusebenzayo lwe-alveoli, u-Huang Bo uthe umphumela wokwelapha okuhlangene okunjalo utholakala ngokufutha emakhaleni ngokwengxenye. Ngesikhathi esifanayo, le nhlanganisela ingadlala indima ye-hormone ephikisana nokuvuvukala. Lokhu kwelashwa ngesifutho kulula, kuphephile, akubizi futhi kulula ukukugqugquzela. Kuyisu elisha lokulawula kusenesikhathi ukutheleleka nge-COVID-19.
Isikhathi sokuthumela: Apr-15-2022