Yini eyabangela izehlakalo ezingaphezu kuka-300 ze-hepatitis eyingozi ye-etiology engaziwa emazweni angaphezu kuka-20 nasezifundeni emhlabeni jikelele? Ucwaningo lwakamuva lukhombisa ukuthi kungahle kuhlobane ne-super antigen edalwe yi-coronavirus entsha. Lokhu okutholwe ngenhla kushicilelwe kujenali yezemfundo egunyaziwe yamazwe ngamazwe “The Lancet Gastroenterology & Hepatology”.
Ucwaningo olushiwo ngenhla lukhombisile ukuthi izingane ezingenwe yi-coronavirus entsha zingaholela ekwakhekeni kwama-virus reservoirs emzimbeni. Ikakhulukazi, ukuba khona okuqhubekayo kwe-coronavirus entsha emgodini wesisu wezingane kungaholela ekukhishweni okuphindaphindiwe kwamaprotheni egciwane kumaseli e-epithelial emathunjini, okuholela ekusebenzeni kokuzivikela komzimba. Lokhu kusebenza okuphindaphindiwe kokuzivikela komzimba kungase kulamule i-super antigen motif kuphrotheni ye-spike ye-coronavirus entsha, efana ne-staphylococcal enterotoxin B futhi iqalise ukusebenza kwe-T cell ebanzi futhi engaqondile. Lokhu kusebenze kwe-super antigen-mediated kwamaseli omzimba kuye kwafakwa ku-multisystem inflammatory syndrome ezinganeni (MIS-C).
Okubizwa ngokuthi i-super antigen (SAg) iwuhlobo lwento engenza kusebenze inombolo enkulu yama-T cell clones futhi ikhiqize impendulo eqinile yokuzivikela komzimba ngokugxilisa okuphansi kakhulu kuphela (≤10-9 M). I-Multisystem inflammatory syndrome ezinganeni yaqala ukunakwa kabanzi ekuqaleni kuka-April 2020. Ngaleso sikhathi, umhlaba wawusanda kungena kubhubhane lomqhele omusha, futhi amazwe amaningi abika ngokulandelana “isifo esiyinqaba sabantwana”, esasihlobene kakhulu nomqhele omusha. isifo segciwane. Iziguli eziningi ziba nezimpawu ezinjengomkhuhlane, ukuqubuka, ukuhlanza, ukuvuvukala kwama-lymph nodes entanyeni, izindebe eziphukile, kanye nesifo sohudo, ezifana nalezi zesifo se-Kawasaki, esaziwa nangokuthi isifo se-Kawasaki. I-Multisystem inflammatory syndrome ezinganeni ivame ukwenzeka emasontweni angu-2-6 ngemva kokutheleleka okusha komqhele, futhi iminyaka yokuqala yezingane igxila phakathi kweminyaka engu-3-10 ubudala. I-Multisystem inflammatory syndrome ezinganeni ihlukile nesifo se-Kawasaki, futhi lesi sifo sibi kakhulu ezinganeni ezihlolwe ukuthi zine-COVID-19.
Abacwaningi bahlaziye ukuthi isifo sokusha kwesibindi kohlobo esibucayi sembangela engaziwa ezinganeni kungenzeka ukuthi satheleleka nge-coronavirus entsha kuqala, futhi izingane zangenwa yi-adenovirus ngemuva kokuvela kwedamu legciwane emathunjini.
Abacwaningi babika isimo esifanayo ekuhlolweni kwegundane: Ukutheleleka kwe-Adenovirus kubangela i-staphylococcal enterotoxin B-mediated shock shock, okuholela ekuhlulekeni kwesibindi nokufa kwamagundane. Ngokusekelwe esimweni samanje, ukubhekwa okuqhubekayo kwe-COVID-19 kuyanconywa esitulweni sezingane ezine-hepatitis eyingozi. Uma ubufakazi be-SARS-CoV-2 superantigen-mediated immune activation butholakala, ukwelashwa kwe-immunomodulatory kufanele kubhekwe ezinganeni ezine-hepatitis eyingozi kakhulu.
Isikhathi sokuthumela: May-21-2022